NanoCelle™ D3 is developed from patent-protected nano-technology creating Vitamin D3 nanoparticles that delivers nanoparticle-sized molecules of the vitamin for absorption across the oral buccal mucosa, bypassing the gastrointestinal tract. NanoCelle™ D3 is indicated to assist in the management of medically diagnosed vitamin D deficiency. Vitamin D3 aids in dietary calcium and phosphorus absorption, important for maintaining healthy bone mineral density. Vitamin D3 binds to the vitamin D receptor (VDR), which is located on all body cells. Activation of the VDR has been shown to regulate hundreds of genes. Because immune cells have the VDR, vitamin D may also assist with immune system function. Vitamin D3 is a fat-soluble vitamin that is naturally synthesised in the body from sun exposure (ultraviolet light) however the amount of vitamin D production depends on geographic location, season, time of day and weather conditions. In addition, clothing habits, lifestyle, and workplace (e.g., indoor versus outdoor), sunscreen use, and sun avoidance practices have an impact on vitamin D synthesis. Vitamin D3 production is also determined by a persons skin type, as the darker pigmented the skin is the less vitamin D3 is produced.