CardiOS is a unique formulation which simultaneously targets cardiovascular, bone health and declining DHEA-Cortisol balance, all of which significantly deteriorate during the ageing process. The formulated ingredients in CardiOS are designed to favourably contribute to reducing these combined elements of chronic disease. CardiOS is beneficial for those approaching mid and later-life to support declining physiology, especially common to both Andropausal men and Menopausal & Post-Menopausal women.

CardiOS is indicated for:

• Cardiovascular disease, incl. endothelial dysfunction with calcification of smooth muscle and arterial plaque
• Osteoporotic and osteopenic bone loss
• Cognitive impairment, affecting working memory and psychomotor performance
• Anxiety, depression, insomnia and related conditions
• Declining antioxidant/ detoxification enzyme activity and impairment in other endogenous defences

Clinical data shows that compounds in CardiOS may:

• Facilitate integration of calcium into bone and to remove unwanted calcium from arteries
• Assist in the synthesis of the bone-forming protein osteocalcin
• Help reduce the morning cortisol levels which promote a degree of heightened anxiety
• Assist in reducing inflammation as well as helping to restore the normal function to the lining of blood vessels.
• Activate cellular defences

Evidence:

Bolland MJ et al. Calcium intake and risk of fracture: systematic review BMJ 2015;351:h4580

McCann JC, Ames BN. Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of ageing? Am J Clin Nutr. 2009;90:889-907

Knapen MH et al. Three-year low-dose menaquinone-7 supplementation helps decrease bone loss in healthy postmenopausal women. Osteoporosis. Int. 2013 Sep;24(9):2499-507.

Knapen MH et al. Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44.

Auddy B et al. A Standardized Withania Somnifera Extract Significantly Reduced Stress-Related Parameters in Chronically-Stressed Humans: A Double-Blind, Randomized, Placebo-Controlled Study. JANA Vol. 11(1):2008.50-56